Recently, a new class of enzyme inhibitors, called COMT inhibitors, has been developed. Like carbidopa, COMT inhibitors prevent the breakdown of levodopa.
The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Two versions of this enzyme are made from the gene. The longer form
Free fulltext PDF articles from hundreds March COMT and MAO-A Polymorphisms and Obsessive COMT and MAO-A Polymorphisms and Obsessive-Compulsive
Four experiments were performed to investigate the anti-akinesia effects of combining a sub-threshold dose (5mg/kg, s.c.) of L-Dopa with different doses and
Combined inhibition of MAO and COMT View Full Page PDF. Regulatory, Integrative and Comparative Physiology® and the APS® logo are
The uptake and subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) of dopamine, adrenaline, isoprenaline and noradrenaline in